Biocompatible hyperbranched polyester magnetic nanocarrier for stimuli-responsive drug release

Abstract

A novel biocompatible magnetic nanocomposite drug carrier was developed by first chemically modifying a hyperbranched polyester (HBPE) with dodecenyl succinic anhydride (DDSA) functional groups to produce HBPE-DDSA. The magnetic nanocomposite Fe₃O₄/HBPE-DDSA was then synthesized by dispersing superparamagnetic iron oxide (Fe₃O₄) nanoparticles within HBPE-DDSA. The structure and magnetic properties of the nanocomposite were characterized by ¹H NMR, MALDI-MS, XRD, FTIR, TEM, and SQUID analyses. Isoniazid (INH) was selected as a model antituberculosis drug to investigate the in vitro drug release properties of Fe₃O₄/HBPE-DDSA/INH. The cytotoxicity of the magnetic nanocomposites was assessed by CCK-8 assay. The results indicated that Fe₃O₄/HBPE-DDSA is a promising potential drug carrier for a magnetic-targeted drug delivery system.