Concepedia

Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function

Rob H. P. Hilgers, Venkatesh Kundumani‐Sridharan, Jaganathan Subramani, Leon C. Chen, Luis G. Cuello, Nancy J. Rusch, Kumuda C. Das

Science Translational Medicine · 2017 · 57 citations · 45 references

DOI

Concepts

Abstract

) generation compared to either saline-injected aged wild-type mice or mice with TRX deficiency. Our study demonstrates a potential translational role of rhTRX in reversing age-related hypertension with long-lasting efficacy.

References

45

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Stefano De Cillà, Serena Farruggio, Stela Vujosevic et al. · Cellular Physiology and Biochemistry · 2017 · 5.1K citations · Full text

, , +16

Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

Bernhard M. Kaess, Jian Rong, Martin G. Larson et al. · JAMA · 2012 · 1.1K citations · Full text

, , +15

[21] Thioredoxin and thioredoxin reductase

Arne Holmgren, Mikael Björnstedt · Methods in enzymology on CD-ROM/Methods in enzymology · 1995 · 943 citations

, , +12

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

R. Daniel Rudic, E G Shesely, Nobuo Maeda et al. · Journal of Clinical Investigation · 1998 · 814 citations · Full text

, , +12

Does superoxide underlie the pathogenesis of hypertension?

Kazutoshi Nakazono, Nozomi Watanabe, Kenjiro Matsuno et al. · Proceedings of the National Academy of Sciences · 1991 · 749 citations

, , +17