Design, synthesis and biological potentials of novel tetrahydroimidazo[1,2-a]pyrimidine derivatives

Abstract

All synthesized derivatives exhibited good antimicrobial, antioxidant and anticancer activity using specific method and compared with standard drugs, especially compounds <b>2, 15</b> and <b>23</b> displayed more activity than reference drugs. Structure activity relationship demonstrated that presence of electron releasing groups of the synthesized compounds enhanced the antibacterial activity against <i>Escherichia coli</i> as well as antioxidant activity and electron withdrawing groups improved the antimicrobial as well as anticancer activity against human breast (MCF-7) cancer cell line.