Obstetrics & Gynecology Science · 2017 · 29 citations · 10 references
MedicineGynecologyObstetricsIn Vitro FertilizationReproductive EndocrinologyReproductive MedicineDiminished Ovarian ReserveFemale InfertilityFertility PreservationOvarian FunctionOvarian ReserveOvarian SurgeryAnti-müllerian Hormone AssessmentAnti-müllerian Hormone TestingFemale Fertility PreservationOocyte In Vitro FertilizationOvarian Reserve DepletionOvarian Reserve DiminutionPregnancy Outcome AssessmentPregnancy Rate Assessment
OBJECTIVE: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patients were evaluated after excluding fertility preservation cases. RESULTS: =0.09). CONCLUSION: DOR caused by previous ovarian surgery may show better pregnancy outcome, whereas that caused by chemotherapy could significantly increase the cycle cancellation rate. Furthermore, patients with DOR who previously received gonadotoxic agents may show reduced efficacy and increased risk of IVF cycle cancellation.
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