SYNTHESIS AND EVALUATION OF SOME BENZOTHIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS

Abstract

<p><strong>Objective: </strong>The objective of the present research investigation involves synthesis and biological evaluation of antidiabetic activity of benzothiazole derivatives.</p><p><strong>Methods: </strong>A novel series of benzothiazole derivatives 7(a-l) were synthesised and synthesised compounds were characterised for different physical and chemical properties like molecular formula, molecular weight, melting point, percentage yield, Rf value, IR, <sup>1</sup>HNMR, <sup>13</sup>CNMR and mass spectroscopy. The newly synthesised benzothiazole derivatives were subsequently assayed <em>in vivo</em> to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats. <strong></strong></p><p><strong>Results: </strong>All the synthesised derivatives showed significant biological efficacy. The compound 7d at 350 mg/kg exerted maximum glucose lowering effects whereas 7c showed minimum glucose lowering effects. All the compounds were effective, and experimental results were statistically significant at p<0.01 and p<0.05 level.<strong></strong></p><p><strong>Conclusion: </strong>From the results, it is clear that compound 7d demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future.</p>