Nature Communications · 2017 · 89 citations · 41 references
Natural SciencesBiomedical EngineeringPhysicsBiophotonicsOpticsPhotonicsFluorescence MicroscopyImagingOptical DetectorsOptical ImagingQuantum OpticsSuper-resolution MicroscopyDetector Quantum EfficiencyDiffraction-limited ImagingPhoton DetectorsPhoton StatisticsQuantum EfficiencySingle-photon DetectionSingle-photon DetectorsSuper-resolution
Despite advances in low-light-level detection, single-photon methods such as photon correlation have rarely been used in the context of imaging. The few demonstrations, for example of subdiffraction-limited imaging utilizing quantum statistics of photons, have remained in the realm of proof-of-principle demonstrations. This is primarily due to a combination of low values of fill factors, quantum efficiencies, frame rates and signal-to-noise characteristic of most available single-photon sensitive imaging detectors. Here we describe an imaging device based on a fibre bundle coupled to single-photon avalanche detectors that combines a large fill factor, a high quantum efficiency, a low noise and scalable architecture. Our device enables localization-based super-resolution microscopy in a non-sparse non-stationary scene, utilizing information on the number of active emitters, as gathered from non-classical photon statistics.
41
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution
Eric Betzig, George H. Patterson, Rachid Sougrat et al. · Science · 2006 · 8.9K citations