Solvent-Responsive Molecularly Imprinted Nanogels for Targeted Protein Analysis in MALDI-TOF Mass Spectrometry

Maddalena Bertolla, Lucia Cenci, Andrea Anesi, Emmanuele Ambrosi, Franco Tagliaro, L. Vanzetti, Graziano Guella, Alessandra Bossi

ACS Applied Materials & Interfaces · 2017 · 62 citations · 38 references

Concepts

Abstract

Molecular imprinted poly(acrylamido)-derivative nanogels have shown their selectivity to bind the protein human serum transferrin (HTR) and also showed their capability for instantaneous solvent-induced modification upon the addition of acetonitrile. Integrated to matrix-assisted laser desorption/ionization time-of-flight mass analysis the HTR-imprinted solvent-responsive nanogels permitted the determination of HTR straight from serum and offered novel perspectives in targeted protein analysis.

References

38