Occurrence of <i>bla</i> _KPC-2 , <i>bla</i> _CTX-M , and <i>mcr-1</i> in Enterobacteriaceae from Well Water in Rural China

Abstract

We report on the coexistence of <i>mcr-1</i> and <i>bla</i>_CTX-M in multidrug-resistant, extended-spectrum β-lactamase-producing <i>Escherichia coli</i> belonging to the sequence type 10 complex isolated from well water in rural China. <i>Raoultella ornithinolytica</i> with <i>bla</i>_KPC-2 was also detected in well water from the same area. This study shows that genes coding for resistance to last-resort antibiotics are present in wells in rural China, indicating a potential source of antibiotic resistance.