Physico-chemical analysis of herbally prepared silver nanoparticles and its potential as a drug bioenhancer

Abstract

In order to exhibit its potential benefits, a drug must cross the epithelial barrier of the intestinal mucosa for transportation into systemic circulation. Several approaches have been proposed to overcome these barriers, including enhancing drug potency through the use of bioenhancers. The concurrent application of bio-enhancers with pharmaceuticals is not a new development, but has been used for thousands of years. The traditional medical system used in India (Ayurveda) has utilized formulations including metal powders (bhasma) to treat a large number of health issues. However, without the support of modern science, these methodologies are largely ignored throughout the western world. Recent studies have begun to examine not only structure and compositional studies but also studies targeted at understanding the mode of action of these materials. Preliminary studies carried out below indicate the potential of these powders to act as non-reactive bio-enhancer for drug delivery.