Nabscessins A and B, Aminocyclitol Derivatives from <i>Nocardia abscessus</i> IFM 10029^T

Abstract

Two new aminocyclitol amide derivatives, nabscessins A ( 1 ) and B ( 2 ), were isolated from the culture broth of a pathogenic actinomycete species, Nocardia abscessus IFM 10029 T . The structures of nabscessins A and B were elucidated by spectral studies, and the compounds showed antifungal activity against Cryptococcus neoformans, with IC 50 values of 32 and 16 μg/mL, respectively.