Omalizumab Is Associated with Reduced Acute Severity of Rhinovirus-triggered Asthma Exacerbation

Abstract

populations, these results should be interpreted in light of their limitations.First, the study population is limited to U.S. ICUs, and the coding algorithms may not generalize internationally.Second, the study was performed in an era of ICD-9 reporting and could not evaluate the performance of ICD-10 codes.However, all claims-based ICU studies are still using ICD-9 codes.Although we would not expect the ICD-10 crosswalk to yield different results, future studies are needed to address this issue.On the basis of these findings, we recommend that researchers can use ICD-9 procedure codes for mechanical ventilation alone to identify populations of mechanically ventilated patients in administrative data, with the understanding that the population captured will not represent the entire population of mechanically ventilated patients.These data suggest that researchers can be confident that identified patients will have truly been ventilated and will help characterize the patients who may have been missed by ICD-9 procedure codes.