Concepedia

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

Lars Philipsen, Amarendra V. Reddycherla, Roland Hartig, Janine Gumz, Matthias Kästle, Andreas Kritikos, Mateusz P. Poltorak, Yury Prokazov, Evgeny Turbin, André Weber,

Science Signaling · 2017 · 68 citations · 39 references

DOI

Concepts

Abstract

The tyrosine kinase Lck must undergo both conformational opening and phosphorylation to transduce signals from the T cell receptor.

References

39

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise et al. · Nature Methods · 2012 · 70.9K citations

, , +9

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow et al. · Journal of Biological Chemistry · 1996 · 2K citations · Full text

, , +17

pEF-BOS, a powerful mammalian expression vector

Seiichi Mizushima, Shigekazu Nagata · Nucleic Acids Research · 1990 · 1.6K citations · Full text

, , +11

Three-dimensional structure of the tyrosine kinase c-Src

Wenqing Xu, Stephen C. Harrison, Michael J. Eck · Nature · 1997 · 1.4K citations

, , +14

Profound block in thymocyte development in mice lacking p56lck

Thierry Jo Molina, Kenji Kishihara, David P. Siderovski et al. · Nature · 1992 · 966 citations

, , +9