Concepedia

An endoplasmic reticulum protein, Nogo‐B, facilitates alcoholic liver disease through regulation of kupffer cell polarization

Jin‐Kyu Park, Mingjie Shao, Moon Young Kim, Soon Koo Baik, Mee-Yon Cho, Teruo Utsumi, Ayano Satoh, Xinsho Ouyang, Chuhan Chung, Yasuko Iwakiri

Hepatology · 2017 · 85 citations · 30 references

DOIFull text

Open access

Abstract

Nogo-B is permissive of M1 polarization of Kupffer cells, thereby accentuating liver injury in ALD in humans and mice. Nogo-B in Kupffer cells may represent a new therapeutic target for ALD. (Hepatology 2017;65:1720-1734).

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