Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide

Abstract

These results show that while selective activation of EP4 or EP2 exerts anti-inflammatory actions, EP4 is the main target of PGE₂ in naïve microglia. The level of EP receptor expression changes from naïve to primed microglia where the COX-2/PGE₂/EP2 axis modulates important adaptive metabolic changes.