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Transition-Metal-Free N9-Amidoalkylation of Purines with N,N-Dialkylamides
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2017
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Enantioselective SynthesisEngineeringBiochemistryNatural SciencesOrganic ChemistryPurine DerivativesSelective N9-amidoalkylationChemistryAmide Nitrogen AtomNatural Product SynthesisChemical DerivativeSynthetic ChemistryTransition-metal-free N9-amidoalkylationBiomolecular Engineering
A novel method for the selective N9-amidoalkylation of purines using <i>N</i>,<i>N</i>-dialkylamides as alkylation reagents via activation of sp<sup>3</sup> C–H bond adjacent to an amide nitrogen atom has been developed in the presence of KI and <i>tert</i>-butyl hydroperoxide (TBHP). This method was simple to operate and provided series of purine derivatives in moderate to excellent yield.