World Journal of Gastroenterology · 2017 · 14 citations · 23 references
MedicineInternal MedicinePharmacotherapyClinical EpidemiologyClinical PharmacologySurvival AnalysisAntithrombotic TherapyGastrointestinal Bleeding ManagementPeptic Ulcer DiseaseSurvival OutcomesThrombosisAntithrombotic-associated BleedingCox RegressionKaplan-meier Confidence IntervalsKaplan-meier Survival EstimatesPrimary Outcome AnalysisRecurrent Peptic Ulcer Disease
AIM: To investigate the long-term prognosis in peptic ulcer patients continuing taking antithrombotics after ulcer bleeding, and to determine the risk factors that influence the prognosis. METHODS: -test. The number of patients that achieved various outcomes was counted and analyzed statistically. A survival curve was drawn using the Kaplan-Meier method, and the difference was compared using the log-rank test. COX regression multivariate analysis was applied to analyze risk factors for the prognosis of peptic ulcer patients. RESULTS: = 0.028). CONCLUSION: After the occurrence of peptic ulcer bleeding, continuing antithrombotics increases the risk of recurrent bleeding events, while discontinuing antithrombotics would increase the risk of death and developing cardiovascular disease. This suggests that clinicians should comprehensively consider the use of antithrombotics after peptic ulcer bleeding.
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Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial.
Joseph J.�Y. Sung, James Y. Lau, Jessica Ching et al. · PubMed · 2010 · 518 citations
Perforated Peptic Ulcer: Main Factors of Morbidity and Mortality
Carlos Noguiera, António Sérgio Silva, Jorge Santos et al. · World Journal of Surgery · 2003 · 164 citations · Full text