Enhance the Bioactivity and Osseointegration of the Polyethylene‐Terephthalate‐Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

Abstract

The objective of this study is to study the bioactivity and osseointegration of polyethylene‐terephthalate‐based artificial ligament coated with mesoporous bioactive glass (MBG) via polydopamine (PDA) in vitro and in vivo. In vitro, the OD value of MC3T3‐E1 cells on PDA‐MBG modified grafts is around 108% higher than that on pure PET after 5 days of culturing. The ALP activity of the PDA‐MBG group is about 1.5 times higher than that of the control group after 7 days of culturing. In the in vivo study, the results demonstrated that more newly formed bone tissue was found and the ultimate failure load increased in the PDA‐MBG coating group. In conclusion, PDA and MBG coating improves the surface bioactivity of the polyethylene‐terephthalate‐based artificial ligament and enhances the osseointegration within a bone tunnel.