Intracellular IL-37b interacts with Smad3 to suppress multiple signaling pathways and the metastatic phenotype of tumor cells

IL-37 is a fundamental inhibitor of innate immunity

Marcel F. Nold, Claudia A. Nold‐Petry, Jarod A. Zepp et al. · Nature Immunology · 2010 · 830 citations

Innate Immune System, Immunology, Autoimmunity +4

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

Marcin Kowanetz, Xiumin Wu, J. Jack Lee et al. · Proceedings of the National Academy of Sciences · 2010 · 658 citations · Full text

Lung Inflammation, Immunology, Immunologic Mechanism +18

Characterization of SIS3, a Novel Specific Inhibitor of Smad3, and Its Effect on Transforming Growth Factor-β1-Induced Extracellular Matrix Expression

Masatoshi Jinnin, Hironobu Ihn, Kunihiko Tamaki · Molecular Pharmacology · 2005 · 441 citations

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Claudia A. Nold‐Petry, Camden Lo, Ina Rudloff et al. · Nature Immunology · 2015 · 430 citations

Inflammation, Cytokine, Innate Signal Transduction +12

Integrin β ₁ -focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

Tsukasa Shibue, Robert A. Weinberg · Proceedings of the National Academy of Sciences · 2009 · 364 citations · Full text

Cell Adhesion, Biological Microenvironments, Cancer Biology +18