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Facile Synthesis and Biological Evaluation of New Mannich Products as Potential Antibacterial, Antifungal and Antituberculosis Agents: Molecular Docking Study
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2016
Year
Combinatorial ChemistryBioorganic ChemistryEngineeringFacile SynthesisOrganic ChemistryChemistryMolecular Docking StudiesChemical EngineeringNovel OrganocatalystsIonic LiquidAntibacterial AgentCatalysisAntimicrobial CompoundPharmacologyNatural Product SynthesisMolecular Docking StudyEnantioselective SynthesisAntifungal AgentNew Mannich ProductsMicrobiologyMedicineSynthetic ChemistryDrug Discovery
Background: In these study we report here one-pot multi-component and solvent free Mannich reaction of U.V. absorbing material, five member heterocyclic ring system and amides/carbamates has been efficiently catalyzed by recyclable ethyl ammonium nitrate as ionic liquid at ambient temperature to produce mannich compounds in high yields. This method has advantages of mild condition, no environmental pollution, and simple work-up procedures to produce new mannich products 4(a-f). The synthesis of five member based heterocycles has been the point of attraction towards their pronounced biological activities and molecular docking studies. Keywords: Multi-component synthesis, heterocyclic compounds, UV absorbing materials, mannich products, molecular docking study.