Chemo- and Regioselective Distal Heteroaryl <i>ipso</i>-Migration: A General Protocol for Heteroarylation of Unactivated Alkenes

Abstract

Herein we report a novel, general protocol for distal heteroaryl ipso-migration and its application to the elusive heteroarylation of unactivated alkenes. A set of nitrogen-containing heteroaryl groups showcase the migratory aptitude. This reaction provides a variety of fluoroalkyl functionalized heteroarenes under mild reaction conditions. This is the first report of a difunctionalization of unactivated alkenes with distal heteroaryl migration.