Recent Progress of Transition-Metal-Catalyzed Enantioselective Hydroalkynylation of Alkenes

Abstract

Catalytic asymmetric hydroalkynylation of unsaturated alkenes provides a straightforward method to construct stereocenters substituted by an alkynyl group. Here we provide an overview of the recent progress of catalytic asymmetric hydroalkynylation reactions. Our recent development of an iridium-catalyzed enantioselective hydroalkynylation of enamides is also discussed. 1 Introduction 2 Catalytic Asymmetric Hydroalkynylation of Electron-Deficient Alkenes 3 Catalytic Asymmetric Hydroalkynylation of Electron-Neutral Alkenes 4 Catalytic Asymmetric Hydroalkynylation of Electron-Rich Alkenes 5 Conclusion