Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

Abstract

Abstract The hydrazide 5 , that was obtained from 1-(4-fluorophenyl)piperazine ( 1 ), was converted to the corresponding carbothioamides 6a–c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a–f was performed via the intermediary of triazoles 7a–c . The condensation of triazoles 7a–c with several heterocyclic amines in the presence of formaldehyde afforded the corresponding N -aminoalkylated triazoles 11–14 . The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reactions was examined. The synthesized compounds were screened for their antimicrobial activities.