<i>N</i> ‐Acylbenzotriazole as Efficient Ligand in Copper‐Catalyzed <i>O</i> ‐Arylation Leading to Diverse Benzoxazoles

Abstract

Abstract An establishment of (1 H ‐benzo[d][1,2,3]triazol‐1‐yl)(2‐methoxyphenyl)methanone as ligand was attained in intramolecular C ‐ O cross‐coupling of N ‐(2‐halophenyl)aryl/alkylamide derivatives to form 2‐Aryl/alkyl benzoxazole derivatives using CuI/K 2 CO 3 as catalytic system. A series of benzoxazoles was developed using this protocol and synthesized compounds were characterized using spectroscopic analysis (IR, MS, 1 H &amp; 13 C NMR). Salient advantages associated with this pathway include easily available starting materials, cheap catalyst, highly stable ligand, wide substrate scope, smooth reaction, easy work‐up and high product yield.