Concepedia

Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma

Sophia Gayle, Sean F. Landrette, Neil Beeharry, Chris Conrad, Marylens Hernandez, Paul Beckett, Shawn M. Ferguson, Talya Mandelkern, Meiling Zheng, Tian Xu,

Blood · 2017 · 206 citations · 46 references

DOIFull text

Open access

Concepts

Abstract

were identified as important determinants of apilimod sensitivity. These findings thus suggest that disruption of lysosomal homeostasis with apilimod represents a novel approach to treat B-NHL.

References

46

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

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Bioconductor: open software development for computational biology and bioinformatics

Robert Gentleman, Vincent J. Carey, Douglas M. Bates et al. · Genome biology · 2004 · 12.5K citations · Full text

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Jordi Barretina, Giordano Caponigro, Nicolas Stransky et al. · Nature · 2012 · 8.5K citations

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Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen, Christopher M. Tan, Yan Kou et al. · BMC Bioinformatics · 2013 · 8.4K citations · Full text

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science · 2013 · 5.5K citations · Full text

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