Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines

Abstract

Cheap and commercially available trichloroisocyanuric acid has been used to promote trifluoromethylation by using TMSCF 3 as the trifluoromethyl source. The method provides a novel and efficient protocol for the construction of CF 3 -containing 4,5-dihydroisoxazoles from allylic oximes in good to excellent yields.