Pediatric Emergency Care · 2017 · 18 citations · 9 references
NursingMaternal HealthObstetricsBreastfeedingPain ManagementPain MedicineAdverse Effects Of AnalgesicsOpioid AnalgesicsOpioid TherapyOpioid ToxicologyPain Management In ChildbirthPostpartum Pain ManagementCesarean Delivery HistoryMaternal Drug SafetyMedication Exposure HistoryMedication Use In BreastfeedingOpioid Side EffectsUrine Toxicology Screening
Opiates are frequently prescribed postpartum for pain relief after cesarean delivery, episiotomies, and headaches. It is estimated that greater than 30% of breast-feeding mothers in the United States are prescribed opiates for pain relief associated with childbirth. Many opiates are readily transferred to human milk, although life-threatening events are rare. We report a 6-day-old breast-feeding infant whose mother was taking hydromorphone for pain relief from a cesarean delivery and whose clinical course was suggestive of opiate toxicity. This case emphasizes the importance of thorough medication history taking in postpartum breast-feeding mothers whose infants may present with symptoms of opiate toxicity. Semisynthetic opiates are frequently not detected on emergency department urine toxicology screens. The pertinent literature is reviewed.
9
Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
Gideon Koren, James Cairns, David Chitayat et al. · The Lancet · 2006 · 678 citations