Pan-azole-resistant<i>Candida tropicalis</i>carrying homozygous<i>erg11</i>mutations at position K143R: a new emerging superbug?

Abstract

A novel point mutation (K143R) located in the erg11 gene of C. tropicalis was found in pan-azole-resistant strains. According to our protein homology model, it is very likely that the mutation K143R causes pan-azole resistance in C. tropicalis . Moreover, an up-regulation of ABC transporters was observed, which can add up to a pan-azole-resistant phenotype.