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Synthesis, Biological Evaluation and Molecular Docking Studies of Pyridine Incorporated Chalcone Derivatives as Anticancer Agents
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2016
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Combinatorial ChemistryImmune ConditionsImmunologyPharmacotherapyAnticancer AgentsChemistryHeterocycle ChemistryCancer ChemotherapyTumor BiologyMolecular Docking StudiesMedicinal ChemistryCancer Cell BiologyBiological EvaluationAnti-cancer AgentMolecular OncologyDetectable CancerCancer ResearchMedicineCancer TreatmentDrug DevelopmentPharmacologyAbnormal CellsNatural SciencesOncologyDrug Discovery
Background: Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Cancer is caused by inherited genetic mutations, hormones, and immune conditions. These factors may act together or in sequence to cause cancer. Ten or more years often pass between exposure to external factors and detectable cancer. Worldwide, one in seven deaths is due to cancer; cancer causes more deaths than AIDS, tuberculosis, and malaria combined. Chemotherapy was one of the important techniques for the treatment of cancer by using several chemotherapeutic agents. It involves the use of cytotoxic agents that destroy rapidly dividing cells. Despite of this progress, the discovery of most potent anti-cancer agents is a challenging issue in cancer chemotherapy without any side effects for the future generations. Keywords: Chalcone, cytotoxicity, derricin, E7010, Lonchocarpin.