Frequency of mutations in rifampicin and isoniazid resistant isolates of M. tuberculosis: an analysis from Central India

Abstract

The patterns and the frequency of the mutations identified in this study indicate the most frequent mutations at S531L codon in the <i>rpoB</i> gene, S315T1 codon in the <i>katG</i> gene and C15T codon in the promoter region of the <i>inhA</i> gene. Controlling the emergence and spread of MDR TB requires an understanding of the evolution of these mutations.