Haem oxygenase‐1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice

Abstract

Although the protective function of HO-1 could be elicited in vivo with both host polymorphisms, the strength of HO-1 induction and suppression of HCV occurred in a polymorphism-dependent manner, indicating that host-genetic determinants may affect disease progression and infection outcome.