PubMed · 2016 · 129 citations · 31 references
MedicineMolecular BiologyOncologyGene ExpressionMolecular OncologyOncogenesCancer ProgressionNoncoding Rna BiologyNoncoding Rna FunctionTranscription Factor OncogenesTumor Suppressor GenesBone Tumor MetastasisCancer-related Noncoding Rna FunctionNoncoding Rna-mediated Gene RegulationOncogenic Noncoding RnaOpen Chromatin DomainsOsteosarcoma RecurrenceTumor Metastasis BiologyTumor Size Prognosis
transcription. There is a significant correlation between the expression of ZEB1-AS1 and ZEB1 in osteosarcoma tissues. ZEB1 depletion abrogates the roles of ZEB1-AS1 on the proliferation and migration of osteosarcoma cells. Collectively, these findings demonstrated that ZEB1-AS1 functions as an oncogene in osteosarcoma via epigenetically activating ZEB1 and could be a potential target for osteosarcoma treatment.
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Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat
Claudia Carrieri, Laura Cimatti, Marta Biagioli et al. · Nature · 2012 · 1K citations · Full text
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers
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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
Aifu Lin, Chunlai Li, Zhen Xing et al. · Nature Cell Biology · 2016 · 575 citations