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Novel 99mTc-Radiolabeled Anionic Linear Globular PEG-Based Dendrimer-Chlorambucil: Non-Invasive Method for In-Vivo Biodistribution
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2016
Year
EngineeringBiomedical EngineeringNanomedicineMedicinal ChemistryMolecular PharmacologyIn-vivo BiodistributionAnionic DendrimerTheranosticsRadiopharmaceutical TherapyClinical ChemistryRadiation OncologyNuclear MedicineMolecular ImagingTherapeutic Drug MonitoringNon-invasive MethodBiochemistryBiomedical AnalysisRcp DeterminationPharmacologyBio-orthogonal ChemistryBiomolecular EngineeringInjected DoseNovel 99Mtc-radiolabeledMedicinePharmacokineticsDrug Analysis
Chlorambucil (CBL) is an alkylating agent, which widely use in the treatment of various types of tumors. The main purpose of this study is to evaluate the in-vivo biodistribution of CBL conjugated to the anionic dendrimer, which has a great ability to labeled with <sup>99m</sup>Tc through binding to carboxylate terminate groups. Whole body scans were used to analyze the percentage of the injected dose in different times. Radiochemical purity (RCP) and in-vivo biodistribution were also calculated with the SPECT/CT instrument. Our study proposes a new method for RCP determination and shows that this carrier is a promising agent to complex with the <sup>99m</sup>Tc and biological assessment.