Concepedia

Paraquat Induces Peripheral Myelin Disruption and Locomotor Defects: Crosstalk with LXR and Wnt Pathways

Mehdi Hichor, Nirmal Kumar Sampathkumar, Julia Montanaro, Didier Borderie, Patrice X. Petit, Victor Gorgievski, Eleni T. Tzavara, Assaad A. Eid, Frédéric Charbonnier, Julien Grenier,

Antioxidants and Redox Signaling · 2016 · 37 citations · 37 references

DOI

Abstract

We demonstrate that PQT instigates peripheral nerve demyelinating neuropathies by enhancing ROS production and deregulating LXR and Wnt pathways. Stimulating Wnt pathway could be a therapeutic strategy for neuropathy treatment. Antioxid. Redox Signal. 27, 168-183.

References

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The Herbicide Paraquat Causes Up-regulation and Aggregation of α-Synuclein in Mice

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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation

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Mitochondria Are a Major Source of Paraquat-induced Reactive Oxygen Species Production in the Brain

Pablo R. Castello, Derek A. Drechsel, Manisha Patel · Journal of Biological Chemistry · 2007 · 474 citations · Full text

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