Ischemic Preconditioning Confers Epigenetic Repression of <i>Mtor</i> and Induction of Autophagy Through G9a‐Dependent H3K9 Dimethylation

Abstract

IPC confers an increase of H3K9me2 levels throughout the Mtor gene-a master regulator of cellular metabolism and a key player in the cardioprotective effect of IPC-leading to transcriptional repression via the methyltransferase G9a. The results of this study indicate that G9a has an important role in regulating cardiac autophagy and the cardioprotective effect of IPC.