LncRNA CRNDE promotes hepatic carcinoma cell proliferation, migration and invasion by suppressing miR-384.

Abstract

. Quantitative real-time polymerase chain reaction (PCR) demonstrated that miR-384 was significantly downregulated in HCC tissues. Moreover, we indicated CRNDE negatively regulated miR-384 expression in HCC. In addition, we found that CRNDE accelerated the expression levels of NF-κB and p-AKT though inhibition of miR-384. Overall, these results suggested that CRNDE-miR-384 axis might be a promising therapeutic target for the treatment of HCC.