Prevention of the Development of Heart Failure with Preserved Ejection Fraction by the Phosphodiesterase-5A Inhibitor Vardenafil in Rats with Type 2 Diabetes

Abstract

We report that vardenafil successfully prevented the development of diabetes mellitus-associated HFpEF. Thus, PDE5A inhibition as a preventive approach might be a promising option in the management of HFpEF patients with diabetes mellitus.