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Publication | Open Access

<i>Adam17</i> Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice

DOIFull Paper Access

65

Citations

48

References

2016

Year

Alexandros Nicolaou, Zhen Zhao, Bernd H. Northoff, Kristina Sass, Andreas Herbst, Alexander Kohlmaier, Athena Chalaris, Christian Wolfrum, Christian Weber, Sabine Steffens,
Arteriosclerosis Thrombosis and Vascular Biology

Abstract

Our results provide evidence for an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFα and TNFR2, thereby preventing overactivation of endogenous TNFR2 signaling in cells of the vasculature.

References

YearCitations

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