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Quantitative determination of five metabolites of aspirin by UHPLC–MS/MS coupled with enzymatic reaction and its application to evaluate the effects of aspirin dosage on the metabolic profile

Metabolic ProfileBiochemistryMedicineEnzymatic ReactionBioanalysisMass SpectrometryMetabolomic ProfilingSecondary MetaboliteAnalytical ChemistryLiquid ChromatographyMetabolic ProfilingMetabolomicsAspirin DosagePharmacologyPharmacokineticsChromatographyDrug Analysis