Concepedia

Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development

Darpan N. Pandya, Nikunj Bhatt, Hong Yuan, Cynthia S. Day, Brandie M. Ehrmann, Marcus W. Wright, Ulrich Bierbach, Thaddeus J. Wadas

Chemical Science · 2016 · 110 citations · 45 references

DOIFull text

Open access

Concepts

Abstract

. These results may inform the development of safer and more robust immuno-PET agents for precision medicine applications.

References

45

Comparative in Vivo Stability of Copper-64-Labeled Cross-Bridged and Conventional Tetraazamacrocyclic Complexes

C. Andrew Boswell, Xiankai Sun, Weijun Niu et al. · Journal of Medicinal Chemistry · 2004 · 480 citations

, , +15

<sup>89</sup>Zr-DFO-J591 for ImmunoPET of Prostate-Specific Membrane Antigen Expression In Vivo

Jason P. Holland, Vadim Divilov, Neil H. Bander et al. · Journal of Nuclear Medicine · 2010 · 409 citations · Full text

, , +17

Standardized methods for the production of high specific-activity zirconium-89

Jason P. Holland, Y. Sheh, Jason S. Lewis · Nuclear Medicine and Biology · 2009 · 408 citations · Full text

, , +6

Radiolabeling and In Vivo Behavior of Copper-64-Labeled Cross-Bridged Cyclam Ligands

Xiankai Sun, Melinda Wuest, Gary R. Weisman et al. · Journal of Medicinal Chemistry · 2001 · 225 citations

, , +14

Preclinical Pharmacokinetics and Biodistribution Studies of <sup>89</sup>Zr-Labeled Pembrolizumab

Christopher G. England, Emily B. Ehlerding, Reinier Hernandez et al. · Journal of Nuclear Medicine · 2016 · 189 citations · Full text

, , +17