Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

Activators and target genes of Rel/NF-κB transcription factors

Heike L. Pahl · Oncogene · 1999 · 3.7K citations

Life Sciences, Genetics, Molecular Biology +14

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

Ann‐Lii Cheng, Chih‐Hung Hsu, Jen‐Kou Lin et al. · PubMed · 2001 · 2.1K citations

Medicine, Oncology, Pharmacology +10

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.

Ricky A. Sharma, Heather R. McLelland, K A Hill et al. · PubMed · 2001 · 829 citations

Medicine, Oncology, Pharmacology +13

Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

Christian Jobin, Cynthia A. Bradham, Maria Pia Russo et al. · PubMed · 1999 · 720 citations

Life Sciences, Cell Biology, Immunology +17

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

Alok C. Bharti, Nicholas J. Donato, Sujay Singh et al. · Blood · 2003 · 683 citations · Full text

Life Sciences, Cell Biology, Pharmacology +17