Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease: a cross‐sectional study of iron‐related magnetic resonance imaging susceptibility

Abstract

Increased nigral iron accumulation in PD appears to be stratified according to disease motor severity and correlates with symptoms related to dopaminergic neurodegeneration. This semi-quantitative in vivo iron assessment could prove useful for objectively monitoring PD progression, especially in clinical trials concerning iron chelation therapies.