2,5-Disubstituted 1,3,4-oxadiazole derivatives of chromeno[4,3- <i>b</i> ]pyridine: synthesis and study of antimicrobial potency

Abstract

Abstract A convenient synthesis of 1,3,4-oxadiazole containing derivatives of chromeno[4,3- b ]pyridine ( 6a–e , 8a–e and 9a–e ) starting from 4-hydroxycoumarin is presented. The synthesized compounds were screened for in vitro antimicrobial activity against representative bacterial and fungal species. The MIC (minimum inhibitory concentration) of the synthesized compounds ranges between 5 and 15 μg/mL, which is comparable with MIC of standard drugs. Compounds 6c , 8c–e , 9c and 9e have the highest potency for certain bacteria and fungi.