PubMed · 2012 · 11 citations · 33 references
MedicineOncologyPathologyCutaneous OncologyDermatopathologyMetastasisCutaneous NeoplasmsMalignant NeoplasmsSkin Cancer Risk FactorsSkin TumorsSquamous Cell CarcinomaStaging Of Skin CancerCutaneous Squamous Cell Carcinoma StagingHigh-risk Cutaneous CarcinomaMetastatic Cutaneous Squamous Cell CarcinomaPrognosis Of Cutaneous MetastasesSkin MetastasesSkin Tumor PrognosisSkin Tumor StagingSquamous Cell Carcinoma Histopathology
The history of most cutaneous squamous cell carcinomas (CSCC) is limited to the skin. However, about 4% of these malignancies are at risk of metastasis and can be life-threatening. This risk is determined by clinical and histological elements which are individually recognized, but so far staging systems allow us neither to assess a risk score, nor to adopt a standardized therapeutical approach. This article reviews prognostic factors for CSCC, and underlines the need for the clinician to have all clinical and histological elements available, in order to try to define the best therapeutical strategy for each case, following up-to-date recommendations.
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
Ulrich K. Laemmli · Nature · 1970 · 251.6K citations