Enantioselective Synthesis of Oxetanes Bearing All‐Carbon Quaternary Stereocenters via Iridium‐Catalyzed C−C Bond‐Forming Transfer Hydrogenation

Abstract

Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C-C coupling of primary alcohols and isoprene oxide. Based on this methodology, an oxetane containing analogue of haloperidol was prepared. A related azetidine formation is also described.