Synergistic interaction between phage therapy and antibiotics clears <i>Pseudomonas aeruginosa</i> infection in endocarditis and reduces virulence

Abstract

Single-dose phage therapy was active against P. aeruginosa EE and highly synergistic with ciprofloxacin. Phage-resistant mutants had impaired infectivity. Phage-therapy alone or combined with antibiotics merits further clinical consideration.