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Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp<sup>3</sup>)−H Bond Activation
139
Citations
37
References
2016
Year
C-h BondBond ActivationCross-coupling ReactionSupramolecular AssemblyEngineeringBiochemistryPrimary AminesNatural SciencesChemical BondMolecular BiologyOrganic ChemistryOrganometallic CatalysisCatalysisChemistryMolecular ChemistrySupramolecular ChemistryBiomolecular EngineeringPalladium-catalyzed Reaction
A palladium-catalyzed reaction of primary amines with iodoarenes produces γ-arylated primary amines. A bulky salicylaldehyde, which is marked as easily available, installable, removable, and recoverable, plays a key role in directing palladium to site-selectively activate the C-H bond located γ to the amino group.
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