Supramolecular β-Cyclodextrin/Multi-walled Carbon Nanotube Paste Electrode for Amperometric Detection of Naproxen

Abstract

The electrochemical behavior of Naproxen (NAP) at a novel β-Cyclodextrin/Multi-walled carbon nanotube paste electrode (β-CD/CNTPE) was investigated. The study was carried out by using cyclic voltammetry (CV) and chronoamperometry (CA) techniques. The overall analysis involved an accumulation step, in which the NAP was adsorbed onto β-cyclodextrin, followed by amperometric quantification of NAP. Various parameters such as amount of β-CD, accumulation time, pH and scan rate were optimized. The proposed electrode showed a good response toward NAP determination. The calibration plot for NAP determination is linear in the range of 0.4 to 23 μg mL−1 under optimum experimental conditions. The limit of detection based on 3sb/b was found to be 0.37 μg mL−1. The proposed electrode (β-CD/CNTPE) presented good repeatability, evaluated in term of relative standard deviation (2.7%) for five replicate measurement. Also, the analytical applicability of the proposed electrode was tested through the analysis of several pharmaceutical preparations.