The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

OATP and P-Glycoprotein Transporters Mediate the Cellular Uptake and Excretion of Fexofenadine

Mirjana Cvetković, Brenda F. Leake, Martin F. Fromm et al. · Drug Metabolism and Disposition · 1999 · 595 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4

Rajinder Bhardwaj, Hartmut Glaeser, Laurent Becquemont et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 533 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.

C.K. Atal, Raghvendra K. Dubey, Jatinder Singh · Journal of Pharmacology and Experimental Therapeutics · 1985 · 353 citations

Pharmacy, Biochemistry, Pharmacology +17

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

Takashi Nozawa, Kozue Imai, Jun-ichi Nezu et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 352 citations

Medicine, Biochemistry, Pharmacology +14