Concepedia

Controlling reactivity through liquid assisted grinding: the curious case of mechanochemical fluorination

Joseph L. Howard, Yerbol Sagatov, Laura Repusseau, Christiane Schotten, Duncan L. Browne

Green Chemistry · 2016 · 137 citations · 36 references

DOI

Concepts

Abstract

We have identified an example of a mechanochemically milled organic reaction where liquid-assisted grinding controls the selectivity, such a phenomenon has not been reported/observed before.

References

36

Introduction of Fluorine and Fluorine‐Containing Functional Groups

Theresa Liang, Constanze N. Neumann, Tobias Ritter · Angewandte Chemie International Edition · 2013 · 2.5K citations · Full text

Fluorine substituent effects (on bioactivity)

Bruce E. Smart · Journal of Fluorine Chemistry · 2001 · 1.4K citations

, , +5

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

Kenneth L. Kirk · Organic Process Research & Development · 2008 · 1.1K citations

, , +13

Fluorine in health care: Organofluorine containing blockbuster drugs

David O’Hagan · Journal of Fluorine Chemistry · 2010 · 835 citations

, , +5

The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome

Tomislav Friščić, S.L. Childs, Syed A. A. Rizvi et al. · CrystEngComm · 2008 · 623 citations

, , +18