Concepedia

AGE/RAGE promotes thecalcification of human aortic smooth muscle cells via the Wnt/β-catenin axis.

Yong Liu, Weiming Wang, Xuelin Zhang, Huqiang He, Xiaolei Sun, Hong Zeng, Xiongfei Xu, Liang Huang, Zhi Zhu, Lei Zhang,

PubMed · 2016 · 20 citations · 12 references

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Abstract

Increased expression of RAGE promoted calcification in HASMCs and up regulated the β-catenin, OPG and Cbfa1 genes. RAGE may activate the downstream genes via the Wntβ-catenin pathway, thereby promoting HASMC differentiation into osteogenic cells and calcification.

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